Two sisters living separate lives on different continents are reunited on a Mediterranean Island. The two barely have time to bond and revive family ties as Kate, the elder, meets a group of locals and agrees to an exciting ride on a hot air balloon. But disaster strikes and as the result of a freak accident, the balloon is carried far out to sea. Their cell phones out of range, and the balloon running out of gas, Kate and her friends are battling for their lives. While, back on land, the younger sister, Liz, has become an unwanted "material witness" to a crime. Matters then take a dramatic twist, one that will mark their lives forever.

　　鮑威爾（安東尼?霍普金斯 Anthony Hopkins 飾）是一位專門研究黑猩猩的人類學家，他在盧旺達長期觀察觀察當地黑猩猩的活動。然而兩年前，這位性情溫和的學者突然性情大變，殺了兩位當地的森林管理員以及傷害了多名管理員后神秘失蹤。如今，他終于被逮捕歸案，關押在美國高度戒嚴的精神病監獄。　　年輕的精神病專家卡爾特（小庫珀?古丁 Cuba Gooding 飾）意圖揭開鮑威爾精神失常之謎而一舉成名，于是他深入到監獄直接與鮑威爾進行對話。鮑威爾一開始對這位訪客充滿敵意，身為人類學家的他在卡爾特面前一點也不落下風。隨著對話的逐漸深入，卡爾特漸漸了解到了事件真相：鮑威爾殺害的管理員其實是偷獵大猩猩的惡棍……

　　好萊塢驚悚大片《密室逃生2》由《速度與激情》系列金牌制片人重磅打造，前作曾創下中國影史進口驚悚片票房冠軍。續作在闖關難度和驚險刺激程度上全面升級，集結全球頂級玩家合力解鎖超高難度密室，開啟命懸一線的殘酷生存之戰。

 本片改編自同名小說，講述了主人公·梓失去了無可替代的摯友而止步不前，她不斷給已故好友發送信息，由此開始，意想不到的邂逅接連發生，形成了一個巨大的圈子…