該片是一部融合科幻驚悚與人性拷問的電影。影片以虛構的西岸港為背景，講述了新聞記者濮欣(徐冬冬飾演)在調查跨國企業賽爾斯集團的污染事件時，意外卷入一場由其父親濮教授(張德暉飾演)所在的孤島實驗室引發的基因災難。當實驗創造出嗜血變異昆蟲并失控后，集團為掩蓋真相切斷聯系、銷毀證據，使被困者陷入絕境。為尋找失聯的父親，濮欣與男友江海(婁淇試驗)潛入死島，在怪物橫行、通訊斷絕的險境中，逐步揭開實驗背后的殘酷陰謀。

四名周末露營者被武裝民兵追捕。

　　紐約，一名女童在登上一輛汽車后遇害身亡，女警梅根（艾麗莎·杜什庫 Eliza Dushku 飾）調查此案，她敏銳的意識到被害女童的姓與名以及案發地三者的首字母相同，但除此之外毫無線索，梅根為查案用盡辦法，然而卻一無所獲，反而梅根本人的精神壓力日漸累積，她開始看到被害女童的幻影，終于精力不支甚至選擇自殺，最后不得不接受精神治療。兩年后，再次有符合首字母規律的女童被害案件發生，此時的梅根不顧上司反對，再次介入調查，她和搭檔在排查多位嫌疑人的同時，這位針對女童的“首字母殺手”作案愈發頻繁。梅根究竟能否拼貼出兇手的真相？　　本片根據真實案件改編。

　　Anna is stuck: she's approaching 30, living like a hermit in her mum's garden shed and wondering why the suffragettes ever bothered. She spends her days making videos using her thumbs as actors - thumbs that bicker about things like whether Yogi Bear is a moral or existential nihilist. But Anna doesn't show these videos to anyone and no one knows what they are for. A week before her birthday her Mum serves her an ultimatum - she needs to move out of the shed, get a haircut that doesn't put her gender in question and stop dressing like a homeless teenager. Naturally, Anna tells her Mum to "back the f-off". However, when her school friend comes to visit, Anna's self-imposed isolation becomes impossible to maintain. Soon she is entangled with a troubled eight year old boy obsessed with Westerns, and the local estate agent whose awkward interpersonal skills continually undermine his attempts to seduce her.